![]() ![]() ![]() Received: JAccepted: AugPublished: September 22, 2010Ĭopyright: © 2010 Charbel Issa et al. PLoS ONE 5(9):Įditor: Karl-Wilhelm Koch, University of Oldenburg, Germany Ranibizumab was shown to be ineffective to prevent such functional loss in macular telangietasia type 2.Ĭitation: Charbel Issa P, Troeger E, Finger R, Holz FG, Wilke R, Scholl HPN (2010) Structure-Function Correlation of the Human Central Retina. Longitudinal data revealed that small lesions affecting the photoreceptor layer typically precede functional detection but later cause severe loss of light sensitivity. In contrast, functional preservation was found if neurodegeneration spared the photoreceptors, but caused quite extensive disruption of the inner retina. There was a significant relationship between outer retinal thickness and retinal sensitivity (p<0.001) and neurodegeneration leaving less than about 50 µm of parafoveal outer retinal thickness completely abolished light sensitivity. The method was applied in a cross-sectional observational study of retinal diseases and in a clinical trial investigating the effectiveness of intravitreal ranibizumab in macular telangietasia type 2. ![]() Custom software allowed for co-registration of the fundus mapped microperimetry coordinates with both SD-OCT and cSLO datasets. Functional mapping of the macula was obtained by using fundus-controlled microperimetry. To obtain high-resolution tomographic and topographic images of the macula spectral-domain optical coherence tomography (SD-OCT) and confocal scanning laser ophthalmoscopy (cSLO), respectively, were used. ![]()
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